Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 5/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543784 | 0.91 | KCNJ1 (0.39) | KCNJ1KCNH2HRH2HRH1CCR5 | |
| SCHEMBL8438015 | 0.91 | KCNJ1 (0.39) | KCNJ1KCNH2HRH2HRH1CCR5 | |
| SCHEMBL8435945 | 0.88 | KCNJ1 (0.40) | KCNJ1KCNH2HRH2HRH1OPRK1 | |
| SCHEMBL8438088 | 0.88 | KCNJ1 (0.40) | KCNJ1KCNH2HRH2HRH1OPRK1 | |
| SCHEMBL8579479 | 0.88 | KCNJ1 (0.40) | KCNJ1KCNH2HRH2HRH1OPRK1 | |
| SCHEMBL8437967 | 0.88 | KCNJ1 (0.40) | KCNJ1KCNH2HRH2HRH1OPRK1 | |
| SCHEMBL8435665 | 0.87 | KCNJ1 (0.38) | KCNJ1KCNH2HRH2HRH1BCHE | |
| SCHEMBL8437995 | 0.86 | HRH2 (0.41) | KCNJ1KCNH2HRH2HRH1BCHE | |
| SCHEMBL8434840 | 0.86 | HRH2 (0.41) | KCNJ1KCNH2HRH2HRH1BCHE | |
| SCHEMBL8439573 | 0.86 | HRH2 (0.41) | KCNJ1KCNH2HRH2HRH1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866564-A | STABILITY | SANKYO COMPANY, LIMITED (JP) | 1999-02-02 | — | — | US | disclosed |
| EP-0518558-B1 | 1-Methylcarbapenem derivatives, their preparation and their use as antibiotics | SANKYO CO (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5712267-A | Carbapenem derivatives, their preparation and their use as antibiotics | SANKYO COMPANY,. LIMITED (JP) | 1998-01-27 | — | — | US | disclosed |
| US-5420119-A | Bactericides | SANKYO COMPANY, LIMITED (JP) | 1995-05-30 | — | — | US | disclosed |
| US-5310735-A | Carbapenem derivatives having antibiotic activity, their preparation and their use | SANKYO COMPANY, LIMITED (JP) | 1994-05-10 | — | — | US | disclosed |
| EP-0518558-A1 | 1-Methylcarbapenem derivatives, their preparation and their use as antibiotics | Sankyo Company Limited (JP) | 1992-12-16 | — | — | EP | disclosed |