Iodide

Iodide

SCHEMBL8438790

CCCCC/C=C\CCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[I-]

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG

The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.47
SOAT2 O75908 1/20 0.43
SOAT1 P35610 1/20 0.43
CHRNA7 P36544 8/20 0.42
EPHX2 P34913 3/20 0.41
FAAH O00519 2/20 0.41
DAGLA Q9Y4D2 1/20 0.40
CNR1 P21554 1/20 0.40
CNR2 P34972 1/20 0.40
PLA2G10 O15496 1/20 0.39
PPARG P37231 1/20 0.39
FFAR1 O14842 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodide SCHEMBL8438793 1.00 HIF1A (0.47) HIF1ASOAT2SOAT1CHRNA7EPHX2
Bromide SCHEMBL27211909 0.97 HIF1A (0.47) HIF1ASOAT2SOAT1CHRNA7EPHX2
Bromide SCHEMBL27230650 0.97 HIF1A (0.47) HIF1ASOAT2SOAT1CHRNA7EPHX2
Iodide SCHEMBL19032656 0.93 HIF1A (0.47) HIF1ASOAT2SOAT1CHRNA7EPHX2
Iodide SCHEMBL11070153 0.93 HIF1A (0.47) HIF1ASOAT2SOAT1CHRNA7EPHX2
Iodide SCHEMBL10731909 0.93 HIF1A (0.47) HIF1ASOAT2SOAT1CHRNA7EPHX2
Iodide SCHEMBL11062977 0.92 SOAT2 (0.46) HIF1ASOAT2SOAT1EPHX2FAAH
Iodide SCHEMBL11062979 0.92 SOAT2 (0.46) HIF1ASOAT2SOAT1EPHX2FAAH
Iodide SCHEMBL11067078 0.90 EPHX2 (0.45) HIF1AEPHX2FAAHCNR1CNR2
Iodide SCHEMBL11067074 0.90 EPHX2 (0.45) HIF1AEPHX2FAAHCNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0675130-B1 Process for the preparation of phosphonium salts SHINETSU CHEMICAL CO (JP) 1999-12-29 EP disclosed
US-5481040-A REACTING A PHOSPHINE WITH A CHLORIDE IN THE PRESENCE OF AN ALKALI METAL SALT AND A SOLVENT SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-01-02 US disclosed
EP-0675130-A2 Process for the preparation of phosphonium salts SHIN-ETSU CHEMICAL CO., LTD. (JP) 1995-10-04 EP disclosed