Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 11/20 | 0.51 |
| ▸ | RARB | P10826 | 7/20 | 0.51 |
| ▸ | RARG | P13631 | 7/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | RXRA | P19793 | 3/20 | 0.43 |
| ▸ | RARA | P10276 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | BLVRB | P30043 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8604289 | 0.81 | CYP26A1 (0.53) | CYP26A1RARBRARGCYP3A4RXRA | |
| SCHEMBL5080286 | 0.78 | RARB (0.71) | CYP26A1RARBRARGCYP3A4RXRA | |
| SCHEMBL8839114 | 0.77 | RARG (0.57) | CYP26A1RARBRARGCYP3A4RXRA | |
| SCHEMBL8839311 | 0.75 | RARG (0.50) | CYP26A1RARBRARGCYP3A4RXRA | |
| SCHEMBL10336597 | 0.72 | RARB (0.62) | CYP26A1RARBRARGCYP3A4RXRA | |
| SCHEMBL8839136 | 0.70 | RARB (0.52) | CYP26A1RARBRARGCYP3A4RXRA | |
| SCHEMBL9350200 | 0.70 | RXRA (0.64) | CYP26A1RARBRARGCYP3A4RXRA | |
| SCHEMBL7871498 | 0.70 | RXRA (0.64) | CYP26A1RARBRARGCYP3A4RXRA | |
| SCHEMBL8103042 | 0.70 | RARB (0.47) | CYP26A1RARBRARGCYP3A4RXRA | |
| SCHEMBL8106316 | 0.69 | CYP26A1 (0.44) | CYP26A1RARBRARGCYP3A4RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001885-A | INHIBITING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN KERATINOCYTES BY ADMINISTERING AT LEAST ONE RETINOID; USEFUL FOR TREATING DISEASES RELATING TO VEGF OVEREXPRESSION, SUCH AS PSORIASIS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 1999-12-14 | — | — | US | claimed |
| US-6001885-A | INHIBITING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN KERATINOCYTES BY ADMINISTERING AT LEAST ONE RETINOID; USEFUL FOR TREATING DISEASES RELATING TO VEGF OVEREXPRESSION, SUCH AS PSORIASIS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 1999-12-14 | — | — | US | disclosed |