Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT3 | P53816 | 1/20 | 0.47 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.47 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438842 | 1.00 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HPGD | |
| SCHEMBL8440368 | 1.00 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HPGD | |
| SCHEMBL8438577 | 1.00 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HPGD | |
| SCHEMBL27495124 | 0.94 | TRPV1 (0.50) | HPGDTRPV1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL8441268 | 0.94 | TRPV1 (0.50) | HPGDTRPV1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL27476952 | 0.94 | TRPV1 (0.50) | HPGDTRPV1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL8440276 | 0.94 | TRPV1 (0.50) | HPGDTRPV1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL8440280 | 0.94 | TRPV1 (0.50) | HPGDTRPV1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL8442701 | 0.93 | TRPV1 (0.48) | HPGDTRPV1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL8440465 | 0.91 | TRPV1 (0.41) | HPGDTRPV1LMNAALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| CN-1175246-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-03-04 | — | — | CN | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |