Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108310 | 0.90 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8108458 | 0.90 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8108459 | 0.90 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8108306 | 0.90 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8108304 | 0.90 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8440370 | 0.88 | TRPV1 (0.47) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8438807 | 0.88 | TRPV1 (0.47) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL9059689 | 0.88 | TRPV1 (0.47) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL27478651 | 0.88 | TRPV1 (0.47) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8439723 | 0.83 | KMT2A (0.43) | TRPV1KMT2ALMNAL3MBTL1ASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | claimed |
| CN-1175246-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-03-04 | — | — | CN | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |