Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.60 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.60 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.60 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.60 |
| ▸ | CHRNG | P07510 | 1/20 | 0.60 |
| ▸ | CHRND | Q07001 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438394 | 1.00 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL8438396 | 1.00 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Hydrochloric Acid SCHEMBL8438229 | 0.99 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Hydrochloric Acid SCHEMBL8438226 | 0.99 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Hydrochloric Acid SCHEMBL8438230 | 0.99 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL7411691 | 0.82 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL8439886 | 0.81 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL8439888 | 0.81 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL8439884 | 0.81 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL7573360 | 0.81 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | claimed |
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | disclosed |