Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.47 |
| ▸ | RELA | Q04206 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895610 | 0.85 | MAPT (0.54) | MAPTSIGMAR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6769989 | 0.82 | SIGMAR1 (0.59) | MAPTSIGMAR1ALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6768842 | 0.81 | SIGMAR1 (0.58) | MAPTSIGMAR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL7101840 | 0.80 | SIGMAR1 (0.53) | MAPTSIGMAR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6768941 | 0.80 | SIGMAR1 (0.55) | MAPTTAAR1SIGMAR1ALDH1A1KMT2A | |
| SCHEMBL6774950 | 0.80 | SIGMAR1 (0.55) | MAPTSIGMAR1ALDH1A1KMT2APOLB | |
| SCHEMBL7098713 | 0.79 | SIGMAR1 (0.51) | MAPTSIGMAR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL7099588 | 0.79 | GAA (0.62) | MAPTSIGMAR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6774845 | 0.79 | NPC1 (0.52) | MAPTSIGMAR1ALDH1A1NOTUMTHRB | |
| SCHEMBL6768523 | 0.79 | KDM4E (0.50) | MAPTTAAR1SIGMAR1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925300-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-06-30 | — | — | EP | claimed |
| EP-0925300-A4 | — | — | 1999-06-30 | — | — | EP | claimed |
| WO-1997030054-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1997-08-21 | — | — | WO | claimed |