SCHEMBL8440941

SCHEMBL8440941

CCOC(=O)/C(Cl)=N\Nc1c(Cl)cc(C(F)(F)F)cc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 1/20 0.58
GPR35 Q9HC97 2/20 0.52
MAPT P10636 2/20 0.50
ALDH1A1 P00352 3/20 0.46
HPGD P15428 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.44
GAA P10253 4/20 0.42
POLB P06746 1/20 0.42
KDM4E B2RXH2 1/20 0.41
NPSR1 Q6W5P4 2/20 0.40
ALOX12 P18054 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
GABRP O00591 1/20 0.39
GABRD O14764 1/20 0.39
GABRA1 P14867 1/20 0.39
GABRB1 P18505 1/20 0.39
GABRG2 P18507 1/20 0.39
GABRB3 P28472 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7707113 1.00 ABCB1 (0.58) ABCB1GPR35MAPTALDH1A1HPGD
SCHEMBL9704137 0.87 ABCB1 (0.55) ABCB1GPR35MAPTALDH1A1HPGD
SCHEMBL9704223 0.87 ABCB1 (0.55) ABCB1GPR35MAPTALDH1A1HPGD
SCHEMBL9703981 0.87 ABCB1 (0.55) ABCB1GPR35MAPTALDH1A1HPGD
SCHEMBL9704778 0.87 ABCB1 (0.55) ABCB1GPR35MAPTALDH1A1HPGD
SCHEMBL9218656 0.86 ABCB1 (0.64) ABCB1GPR35MAPTALDH1A1HPGD
SCHEMBL9218647 0.86 ABCB1 (0.64) ABCB1GPR35MAPTALDH1A1HPGD
SCHEMBL9215583 0.85 ABCB1 (0.63) ABCB1GPR35MAPTALDH1A1HPGD
SCHEMBL9215587 0.85 ABCB1 (0.63) ABCB1GPR35MAPTALDH1A1HPGD
SCHEMBL11758622 0.85 ABCB1 (0.78) ABCB1GPR35MAPTALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0967206-A1 Derivatives of N-phenylpyrazoles RHONE POULENC AGRICULTURE LTD. (GB) 1999-12-29 EP disclosed
US-5916618-A PESTICIDE FOR MEDICATED FEEDSTUFF, DIETARY CONCENTRATE OR SUPPLEMENT RHONE-POULENC AGRICULTURE LTD. (GB) 1999-06-29 US disclosed
US-5714191-A PESTICIDES USED IN MEDICATED FEEDSTUFF, MINERAL SALT LICK OR EDIBLE BAIT RHONE-POULENC AGRICULTURE LTD. (GB) 1998-02-03 US disclosed
US-5608077-A INSECTICIDES, NEMATOCIDES, ANTHELMINTICS, ANTIPROTOZOA AGENTS RHONE-POULENC AGRICULTURE LTD. (GB) 1997-03-04 US disclosed
US-5547974-A INSECTICIDES, NEMATOCIDES, ANTHELMINTICS RHONE-POULENC AGRICULTURE LTD. (GB) 1996-08-20 US disclosed
EP-0234119-B1 Pesticidal method using N-phenylpyrazoles RHONE POULENC AGROCHIMIE (FR) 1994-08-24 EP disclosed
EP-0579280-A1 Pesticidal method using N-phenylpyrazoles RHONE-POULENC AGROCHIMIE (FR) 1994-01-19 EP disclosed
US-5232940-A Controlling insects, plant nematodes, helminths, protozoa BASF AGRO B.V., ARNHEM (NL), WADENSWIL-BRANCH (CH) 1993-08-03 US disclosed
WO-1987003781-A1 PESTICIDAL METHOD USING N-PHENYLPYRAZOLES MAY & BAKER LIMITED (GB) 1987-07-02 WO disclosed