Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17858501 | 0.80 | PDE2A (0.46) | PDE2ACYP3A4MAPK1CYP1A2CYP2D6 | |
| SCHEMBL9806515 | 0.80 | PDE2A (0.42) | PDE2ACYP3A4CYP1A2CYP2D6NFKB1 | |
| SCHEMBL14373062 | 0.80 | CYP3A4 (0.41) | PDE2ACYP3A4MAPK1CYP1A2CYP2D6 | |
| SCHEMBL7546175 | 0.79 | CYP1A2 (0.63) | PDE2ACYP3A4CYP1A2CYP2D6NFKB1 | |
| SCHEMBL12061470 | 0.79 | PDE2A (0.40) | PDE2ACYP3A4LMNAALDH1A1 | |
| SCHEMBL11501879 | 0.78 | CYP3A4 (0.40) | PDE2ACYP3A4MAPK1CYP1A2CYP2D6 | |
| SCHEMBL17069821 | 0.77 | PDE2A (0.39) | PDE2ANOTUM | |
| SCHEMBL17553337 | 0.76 | CYP3A4 (0.39) | CYP3A4MAPK1CYP1A2CYP2D6NFKB1 | |
| SCHEMBL8440315 | 0.76 | P2RX7 (0.46) | CYP3A4MAPK1CYP1A2CYP2D6NFKB1 | |
| SCHEMBL16958286 | 0.76 | CYP3A4 (0.39) | CYP3A4MAPK1CYP1A2CYP2D6NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604857-B1 | Process for preparing optically active 4-mercapto-2-pyrrolidone derivative and intermediate therefor | TANABE SEIYAKU CO (JP) | 1999-03-17 | — | — | EP | disclosed |
| US-5495012-A | Process for preparing optically active 4-mercapto-2-pyrrolidone derivative and intermediate therefor | TANABE SEIYAKU CO., LTD. (JP) | 1996-02-27 | — | — | US | disclosed |
| US-5424446-A | Process for preparing optically active 4-mercapto-2-pyrrolidone derivative and intermediate therefor | TANABE SEIYAKU CO., LTD. (JP) | 1995-06-13 | — | — | US | disclosed |
| EP-0604857-A1 | Process for preparing optically active 4-mercapto-2-pyrrolidone derivative and intermediate therefor | TANABE SEIYAKU CO., LTD. (JP) | 1994-07-06 | — | — | EP | disclosed |