Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 18/20 | 0.45 |
| ▸ | PPARA | Q07869 | 17/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444677 | 0.85 | PPARG (0.47) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL8441980 | 0.81 | PPARG (0.35) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL4885386 | 0.72 | PPARG (0.49) | PPARGPPARAIKBKB | |
| SCHEMBL7909907 | 0.70 | FFAR1 (0.59) | PPARGPPARA | |
| SCHEMBL5761525 | 0.69 | IKBKB (0.46) | PPARGPPARAIKBKBUSP2SMN1; SMN2 | |
| SCHEMBL5425749 | 0.69 | PPARG (0.74) | PPARGPPARA | |
| SCHEMBL5918538 | 0.69 | PPARG (0.52) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL13633788 | 0.68 | IKBKB (0.47) | PPARGPPARAIKBKB | |
| SCHEMBL4885480 | 0.68 | PPARG (0.51) | PPARGPPARAIKBKB | |
| SCHEMBL9245429 | 0.68 | PPARG (0.52) | PPARGPPARACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939445-A | ISOXAZOLIDINEDIONES COMPOUNDS AS HYPOGLYCEMIC AGENTS AND TREATMENT OF ARTERIOSCLEROSIS | JAPAN TOBACCO, INC. (JP) | 1999-08-17 | — | — | US | disclosed |
| US-5728720-A | HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; TREATMENT OF DIABETES | JAPAN TOBACCO INC. (JP) | 1998-03-17 | — | — | US | disclosed |