Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 19/20 | 0.35 |
| ▸ | PPARA | Q07869 | 16/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444677 | 0.85 | PPARG (0.47) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL8441985 | 0.81 | PPARG (0.45) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL9246656 | 0.72 | KDM4E (0.39) | PPARGPPARAALDH1A1PPARD | |
| SCHEMBL8892118 | 0.69 | PDE4B (0.37) | PPARGPPARAALDH1A1 | |
| SCHEMBL5918535 | 0.69 | PPARG (0.44) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL9245425 | 0.68 | PPARG (0.49) | PPARGPPARAALDH1A1CYP3A4 | |
| SCHEMBL9245437 | 0.67 | PPARG (0.46) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL8440670 | 0.66 | PPARG (0.46) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL8445498 | 0.65 | PPARG (0.47) | PPARGPPARAPPARD | |
| SCHEMBL8440666 | 0.64 | PPARG (0.47) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939445-A | ISOXAZOLIDINEDIONES COMPOUNDS AS HYPOGLYCEMIC AGENTS AND TREATMENT OF ARTERIOSCLEROSIS | JAPAN TOBACCO, INC. (JP) | 1999-08-17 | — | — | US | disclosed |
| US-5728720-A | HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; TREATMENT OF DIABETES | JAPAN TOBACCO INC. (JP) | 1998-03-17 | — | — | US | disclosed |