Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 6/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 5/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 5/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.37 |
| ▸ | PLK4 | O00444 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378295 | 0.90 | CSNK1D (0.51) | CSNK1DMAPK1MAPK3MAP2K4MAPKAPK3 | |
| SCHEMBL5372338 | 0.88 | CSNK1D (0.49) | CSNK1DMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL8442884 | 0.88 | CSNK1D (0.44) | CSNK1DMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL5383966 | 0.86 | CSNK1D (0.49) | CSNK1DMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL5372967 | 0.85 | CSNK1D (0.64) | CSNK1DMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL5393207 | 0.85 | CSNK1D (0.47) | CSNK1DMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL5383738 | 0.85 | CSNK1D (0.48) | CSNK1DMAPK1MAPK3MAP2K4MAPKAPK3 | |
| SCHEMBL5377949 | 0.84 | CSNK1D (0.54) | CSNK1DMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL5387313 | 0.84 | CSNK1D (0.52) | CSNK1DMAP2K4DYRK1ANTRK1CLK2 | |
| SCHEMBL5378169 | 0.82 | CSNK1D (0.44) | CSNK1DMAPK1MAP2K4MAPKAPK3MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC | 2005-01-13 | — | — | US | disclosed |
| US-20040127536-A1 | Methods for treating an inflammatory condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127536-A1 | Methods for treating an inflammatory condition or inhibiting JNK | MAPK1, MAP3K1, MAPKAPK2 | CSNK1D 349/4885MAPK1 1/4885MAPK3 22/4885 |
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | GPR119, JAK3, IGF1R | CSNK1D 410/4885MAPK1 52/4885MAPK3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.