Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 13/20 | 0.62 |
| ▸ | ESR1 | P03372 | 13/20 | 0.62 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.62 |
| ▸ | TOP1 | P11387 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541061 | 0.97 | HRAS (0.58) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7125320 | 0.85 | HRAS (0.83) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL7826181 | 0.82 | KDM4E (0.40) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7838507 | 0.81 | HRAS (0.40) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL14002814 | 0.77 | HRAS (1.00) | HRASESR1ESR2TOP1KDM4E | |
| Stallimycin SCHEMBL108585 | 0.77 | HRAS (1.00) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7838380 | 0.77 | TOP1 (0.42) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7810272 | 0.76 | TOP1 (0.41) | HRASESR1ESR2TOP1KDM4E | |
| Stallimycin SCHEMBL193003 | 0.76 | KDM4E (1.00) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL9038223 | 0.76 | HRAS (0.49) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915845-A1 | ACRYLOYL SUBSTITUTED DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004524-A1 | ACRYLOYL SUBSTITUTED DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-02-05 | — | — | WO | disclosed |