SCHEMBL8444036

SCHEMBL8444036

CC(NCCCn1ccnc1-c1ccccc1)c1ccc(Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATP1A1 P05023 2/20 0.46
ATP1B1 P05026 2/20 0.46
ATP1A3 P13637 2/20 0.46
ATP1B2 P14415 2/20 0.46
ATP1A2 P50993 2/20 0.46
ATP1B3 P54709 2/20 0.46
FXYD2 P54710 2/20 0.46
ATP1A4 Q13733 2/20 0.46
ESR1 P03372 1/20 0.44
SCN8A Q9UQD0 1/20 0.43
HTR1A P08908 3/20 0.41
HTR7 P34969 2/20 0.41
HTR6 P50406 2/20 0.41
CYP3A4 P08684 3/20 0.39
CYP2C19 P33261 3/20 0.39
TSHR P16473 1/20 0.39
CYP2C9 P11712 1/20 0.38
HIF1A Q16665 1/20 0.38
P2RX7 Q99572 1/20 0.38
BRD4 O60885 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8444345 0.98 ATP1A1 (0.45) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL8443583 0.84 CA12 (0.47) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
Hydrochloric Acid SCHEMBL8446831 0.83 CA12 (0.46) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL8443907 0.82 ATP1A1 (0.41) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL8446245 0.81 KCNH2 (0.46) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL8447110 0.80 KCNH2 (0.43) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL8443385 0.80 ATP1A1 (0.46) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
Hydrochloric Acid SCHEMBL8445806 0.79 KCNH2 (0.42) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL27294495 0.77 ESR1 (0.46) ESR1CYP3A4CYP2C19TSHRCYP2C9
SCHEMBL13202786 0.76 ESR1 (0.56) ESR1CYP3A4CYP2C19TSHRCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5547972-A 1-(ARLALKYLAMINOALKYL) IMIDAZOLE DERIVATIVES THE BOOTS COMPANY PLC (GB) 1996-08-20 US claimed
EP-0618907-B1 1-(ARYLALKYL-AMINOALKYL)IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARATION AND USE AS THERAPEUTICAL AGENTS BRITISH TECH GROUP INT (GB) 1999-04-28 EP disclosed
US-5547972-A 1-(ARLALKYLAMINOALKYL) IMIDAZOLE DERIVATIVES THE BOOTS COMPANY PLC (GB) 1996-08-20 US disclosed
EP-0618907-A1 1-(ARYLALKYL-AMINOALKYL)IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARATION AND USE AS THERAPEUTICAL AGENTS Knoll AG (DE) 1994-10-12 EP disclosed
WO-1993013075-A1 1-(ARYLALKYL-AMINOALKYL)IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARATION AND USE AS THERAPEUTICAL AGENTS THE BOOTS COMPANY PLC (GB) 1993-07-08 WO disclosed