Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 7/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20645838 | 0.77 | MIF (0.50) | MIFHTTCYP1A2CYP2D6CYP3A4 | |
| SCHEMBL20640947 | 0.77 | MIF (0.50) | MIFHTTCYP1A2CYP2D6CYP3A4 | |
| SCHEMBL20640929 | 0.77 | MIF (0.50) | MIFHTTCYP1A2CYP2D6CYP3A4 | |
| SCHEMBL12556064 | 0.74 | MIF (1.00) | MIFHTTCYP1A2CYP2D6CYP3A4 | |
| SCHEMBL22861383 | 0.74 | MIF (1.00) | MIFHTTCYP1A2CYP2D6CYP3A4 | |
| SCHEMBL20645845 | 0.74 | MIF (0.48) | MIFHTTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL27550992 | 0.73 | MIF (0.47) | MIFHTTCYP1A2CYP2D6CYP3A4 | |
| SCHEMBL20640544 | 0.73 | MIF (0.50) | MIFHTTCYP1A2CYP2D6CYP3A4 | |
| SCHEMBL27433856 | 0.73 | MIF (0.47) | MIFHTTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL10757347 | 0.72 | MIF (0.46) | MIFHTTHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256186-B2 | Gamma secretase inhibitors | SCHERING CORPORATION (US) | 2007-08-14 | — | — | US | disclosed |
| US-20050085506-A1 | Novel gamma secretase inhibitors | SCHERING-PLOUGH CORPORATION AND PHARMACOPEIA, INC. | 2005-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085506-A1 | Novel gamma secretase inhibitors | BACE1, BACE2, APP | MIF 4307/4885HTT 640/4885CYP1A2 1212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.