SCHEMBL8445001

SCHEMBL8445001

ClCOC(CCOCc1ccccc1)OCc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.45
HTT P42858 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CA1 P00915 4/20 0.39
CYP2C19 P33261 1/20 0.38
NAAA Q02083 1/20 0.37
FOLH1 Q04609 1/20 0.37
CA2 P00918 2/20 0.37
CA7 P43166 2/20 0.37
CA9 Q16790 2/20 0.37
SLC6A2 P23975 2/20 0.36
SLC6A4 P31645 2/20 0.36
SLC6A3 Q01959 2/20 0.36
ALDH1A1 P00352 1/20 0.36
TACR1 P25103 2/20 0.36
LTA4H P09960 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9715485 0.79 TSHR (0.48) TSHRHTTSMN1; SMN2CA1CYP2C19
SCHEMBL26601450 0.75 TSHR (0.52) TSHRHTTSMN1; SMN2CA1CYP2C19
SCHEMBL8712990 0.74 TSHR (0.56) TSHRHTTSMN1; SMN2CA1CYP2C19
SCHEMBL4535809 0.74 KMT2A (0.49) TSHRHTTSMN1; SMN2CA1CYP2C19
SCHEMBL344059 0.74 TSHR (0.61) TSHRHTTSMN1; SMN2CA1NAAA
SCHEMBL31697649 0.74 TSHR (0.48) TSHRCA1CYP2C19CA2CA7
SCHEMBL17863583 0.74 TSHR (0.48) TSHRCA1CYP2C19CA2CA7
SCHEMBL4536001 0.74 CA1 (0.50) TSHRHTTSMN1; SMN2CA1CYP2C19
SCHEMBL11957470 0.74 TSHR (0.40) TSHRHTTCYP2C19SLC6A2SLC6A4
SCHEMBL30380288 0.72 TSHR (0.48) TSHRHTTSMN1; SMN2CA1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE36187-E HERPES SIMPLEX VIRUS; HUMAN CYTOMEGALOVIRUS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1999-04-06 US disclosed
US-5360795-A Treating cytomegalo virus and herpes simplex viruses THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1994-11-01 US disclosed
US-4968686-A DECREASED CYTOTOXICITY; CYTOMEGALO AND HERPEX SIMPLEX VIRUSES THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1990-11-06 US disclosed