Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.41 |
| ▸ | EED | O75530 | 4/20 | 0.40 |
| ▸ | RBBP4 | Q09028 | 4/20 | 0.40 |
| ▸ | SUZ12 | Q15022 | 4/20 | 0.40 |
| ▸ | EZH2 | Q15910 | 4/20 | 0.40 |
| ▸ | GRM5 | P41594 | 4/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8450015 | 0.87 | MAOA (0.39) | CDK9 | |
| SCHEMBL6396778 | 0.78 | MAOA (0.64) | — | |
| SCHEMBL6396782 | 0.78 | MAOA (0.64) | — | |
| SCHEMBL7121158 | 0.78 | PDK4 (0.45) | PDK4NAMPTPRMT5WDR77GRM5 | |
| SCHEMBL8445812 | 0.78 | MAOA (0.40) | CDK9HTR6 | |
| SCHEMBL7027197 | 0.77 | MAOA (0.44) | PDK4PRMT5WDR77EEDRBBP4 | |
| SCHEMBL27025947 | 0.76 | GRM1 (0.53) | PDK4NAMPTGRM5GRM1TNF | |
| SCHEMBL1199494 | 0.74 | GRM5 (0.55) | PDK4NAMPTGRM5GRM1TNF | |
| SCHEMBL8655743 | 0.74 | MAOA (0.44) | — | |
| SCHEMBL6396651 | 0.74 | MAOA (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912561-A1 | 3-PHENYL-FURAN-(5H)-2-ONE AND DIHYDROFURAN-2-ONE DERIVATIVES AS ANTIBACTERIAL AGENTS | AstraZeneca AB (SE) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997043280-A1 | 3-PHENYL-FURAN-(5H)-2-ONE AND DIHYDROFURAN-2-ONE DERIVATIVES AS ANTIBACTERIAL AGENTS | ZENECA LIMITED (GB) | 1997-11-20 | — | — | WO | disclosed |