Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23259093 | 0.91 | GFER (0.83) | GFERALDH1A1HTTMAPK14MEN1 | |
| SCHEMBL24358707 | 0.90 | GFER (0.81) | GFERALDH1A1HTTMAPK14MEN1 | |
| SCHEMBL27327850 | 0.87 | GFER (0.77) | GFERALDH1A1HTTMAPK14MEN1 | |
| SCHEMBL8442556 | 0.85 | GFER (0.73) | GFERALDH1A1HTTMAPK14USP2 | |
| SCHEMBL615956 | 0.85 | AVPR1A (0.77) | GFERALDH1A1HTTMAPK14MEN1 | |
| SCHEMBL7809783 | 0.83 | GFER (0.70) | GFERALDH1A1HTTMAPK14MEN1 | |
| SCHEMBL20181880 | 0.83 | ALDH1A1 (0.75) | GFERALDH1A1HTTMAPK14USP2 | |
| SCHEMBL9410743 | 0.83 | GFER (0.71) | GFERALDH1A1HTTMAPK14KMT2A | |
| SCHEMBL948677 | 0.83 | GFER (0.71) | GFERALDH1A1HTTMAPK14LMNA | |
| SCHEMBL27304741 | 0.83 | GFER (0.70) | GFERALDH1A1HTTMAPK14AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922042-A1 | NOVEL PIPERAZINE CONTAINING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998006715-A1 | NOVEL PIPERAZINE CONTAINING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-19 | — | — | WO | disclosed |