Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 19/20 | 0.53 |
| ▸ | EDNRB | P24530 | 18/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8441536 | 0.93 | EDNRA (0.61) | EDNRAEDNRB | |
| SCHEMBL8441661 | 0.93 | EDNRA (0.52) | EDNRAEDNRB | |
| SCHEMBL8444966 | 0.92 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL8444398 | 0.88 | EDNRA (0.48) | EDNRAEDNRB | |
| SCHEMBL7565518 | 0.87 | EDNRA (0.69) | EDNRAEDNRB | |
| SCHEMBL7566467 | 0.81 | EDNRA (0.78) | EDNRAEDNRB | |
| SCHEMBL7574597 | 0.81 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL8444958 | 0.81 | EDNRA (0.42) | EDNRAEDNRB | |
| SCHEMBL7569554 | 0.80 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL7565787 | 0.79 | EDNRA (0.69) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962682-A | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | claimed |
| US-5962682-A | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | disclosed |