Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 4/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP1 | P63208 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1746280 | 0.88 | ADORA1 (0.38) | ADORA1ADORA2APDE4BLMNATP53 | |
| SCHEMBL8442661 | 0.84 | ACACB (0.38) | ABCB1USP30ACACBACACAGPR119 | |
| SCHEMBL8443924 | 0.81 | BUB1 (0.44) | ABCB1USP30UCHL1ACACBACACA | |
| SCHEMBL8444864 | 0.78 | USP30 (0.37) | ABCB1USP30UCHL1ACACBACACA | |
| SCHEMBL8442660 | 0.72 | USP30 (0.39) | USP30UCHL1PDE4B | |
| SCHEMBL8446562 | 0.71 | PDE4B (0.41) | USP30ADORA1ADORA2APDE4BLMNA | |
| SCHEMBL1746373 | 0.70 | PDE4B (0.39) | USP30ADORA1ADORA2APDE4BALDH1A1 | |
| SCHEMBL8442662 | 0.69 | BUB1 (0.37) | GPR119PDE4BSCN9AALDH1A1 | |
| SCHEMBL1746529 | 0.67 | ADORA1 (0.38) | ADORA1ADORA2APDE4BLMNAALDH1A1 | |
| SCHEMBL6080636 | 0.66 | KLK7 (0.41) | USP30GPR119CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380890-A1 | New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-10-26 | — | — | EP | disclosed |