Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 3/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584620 | 0.82 | EDNRA (0.43) | GUSBNR4A2SPRMEN1KMT2A | |
| SCHEMBL8444123 | 0.76 | GUSB (0.36) | GUSBNR4A2HPGDMEN1NPBWR1 | |
| SCHEMBL8305533 | 0.73 | TAS1R3 (0.42) | TAS1R3TAS1R1CYP2A6 | |
| SCHEMBL8448325 | 0.72 | TAS1R3 (0.43) | TAS1R3TAS1R1CYP2A6 | |
| SCHEMBL6584567 | 0.69 | EDNRA (0.41) | GUSBITGB2ICAM1ITGALSPR | |
| SCHEMBL10272715 | 0.68 | NR4A2 (0.44) | GUSBNR4A2CYP2A6CHRNB2CHRNA7 | |
| SCHEMBL6584222 | 0.68 | EDNRA (0.39) | GUSBNR4A2MEN1NPBWR1KMT2A | |
| SCHEMBL10272717 | 0.65 | NR4A2 (0.41) | GUSBNR4A2MEN1KMT2ACYP2A6 | |
| SCHEMBL5881120 | 0.65 | NR4A2 (0.55) | NR4A2MEN1KMT2A | |
| SCHEMBL14631682 | 0.64 | NR4A2 (0.57) | GUSBNR4A2MEN1KMT2AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901470-A1 | INDOLE DERIVATIVES USEFUL AS ENDOTHELIN RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043260-A1 | INDOLE DERIVATIVES USEFUL AS ENDOTHELIN RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1997-11-20 | — | — | WO | disclosed |