Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.78 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.76 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1890253 | 0.99 | HDAC6 (0.78) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| Hydrochloric Acid SCHEMBL1890256 | 0.99 | HDAC6 (0.78) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL8446079 | 0.89 | HDAC6 (0.79) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| Hydrochloric Acid SCHEMBL1888891 | 0.88 | HDAC6 (0.80) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| Hydrochloric Acid SCHEMBL1888889 | 0.88 | HDAC6 (0.80) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| Resminostat SCHEMBL295540 | 0.87 | HDAC1 (1.00) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| Resminostat SCHEMBL295541 | 0.87 | HDAC1 (1.00) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| Resminostat SCHEMBL1887874 | 0.86 | HDAC1 (1.00) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| Resminostat SCHEMBL1887878 | 0.86 | HDAC1 (1.00) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| Resminostat SCHEMBL299845 | 0.85 | HDAC1 (0.96) | HDAC6HDAC1HDAC3HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785659-B2 | Method for the production of sulphonylpyrroles as HDAC inhibitors | 4SC AG (DE) | 2014-07-22 | — | — | US | disclosed |
| US-20110105568-A1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2011-05-05 | — | — | US | disclosed |
| WO-2009112529-A1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2009-09-17 | — | — | WO | disclosed |
| EP-2100878-A1 | Novel method for the production of sulphonylpyrroles as HDAC inhibitors | 4SC AG (DE) | 2009-09-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105568-A1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | HDAC1, HDAC2, HDAC3 | HDAC6 10/4885HDAC1 1/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.