Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ANO1 | Q5XXA6 | 4/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689464 | 0.82 | LMNA (0.49) | EPHX2LMNAANO1CTSBCTSL | |
| SCHEMBL24974708 | 0.82 | LMNA (0.49) | EPHX2LMNAANO1CTSBCTSL | |
| SCHEMBL12315745 | 0.81 | PHF8 (0.45) | EPHX2LMNAANO1CTSBCTSL | |
| SCHEMBL3001083 | 0.79 | EPHX2 (0.37) | EPHX2LMNAANO1CTSBCTSL | |
| SCHEMBL8444167 | 0.78 | LMNA (0.35) | LMNACTSBCTSLALDH1A1 | |
| SCHEMBL12316377 | 0.78 | EPHX2 (0.42) | EPHX2LMNAHDAC3HDAC1HDAC6 | |
| SCHEMBL5143779 | 0.78 | DPP4 (0.35) | LMNAANO1DPP4HDAC3HDAC1 | |
| SCHEMBL8684589 | 0.78 | ANO1 (0.37) | LMNAANO1DPP4HDAC3HDAC1 | |
| SCHEMBL852232 | 0.78 | HDAC3 (0.37) | LMNAANO1DPP4HDAC3HDAC1 | |
| SCHEMBL13146756 | 0.77 | EPHX2 (0.45) | EPHX2LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395313-B1 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PROD (US) | 1999-12-15 | — | — | EP | disclosed |
| US-4988814-A | Antidepressants and/or anxiolytic agents | AMERICAN HOME PRODUCTS CORP. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0395313-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-31 | — | — | EP | disclosed |