Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TPMT | P51580 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.35 |
| ▸ | CTSV | O60911 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | EIF4E | P06730 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12574256 | 0.73 | PKM (0.49) | PKMTSHRPOLBTDP1SMN1; SMN2 | |
| SCHEMBL5153986 | 0.73 | HSD17B10 (0.42) | PKMTSHRKDM4EPOLBTDP1 | |
| SCHEMBL28664035 | 0.73 | CA1 (0.39) | TSHRKDM4EPOLBTDP1SMN1; SMN2 | |
| SCHEMBL29740471 | 0.69 | PKM (0.59) | PKMTSHRKDM4EPOLBCTDSP1 | |
| SCHEMBL104452 | 0.69 | PKM (0.59) | PKMTSHRKDM4EPOLBCTDSP1 | |
| SCHEMBL1116033 | 0.68 | PKM (0.54) | PKMKDM4EPOLBCTDSP1TDP1 | |
| SCHEMBL30252887 | 0.67 | TDP1 (0.54) | PKMTSHRTDP1ALDH1A1TP53 | |
| SCHEMBL12262070 | 0.67 | TSHR (0.46) | PKMTSHRPOLBTDP1L3MBTL1 | |
| SCHEMBL621983 | 0.67 | PKM (0.69) | PKMTSHRKDM4EPOLBCTDSP1 | |
| SCHEMBL30105934 | 0.67 | PKM (0.69) | PKMTSHRKDM4EPOLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942387-A | Combinatorial process for preparing substituted thiophene libraries | ELI LILLY AND COMPANY (US) | 1999-08-24 | — | — | US | disclosed |
| WO-1998008839-A1 | COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED THIOPHENE LIBRARIES | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |