SCHEMBL8447084

SCHEMBL8447084

Cc1c(C(=O)N=C(N)N)cc(S(C)(=O)=O)cc1-n1cccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC9A1 P19634 2/20 0.64
SLC9A3 P48764 1/20 0.64
SLC9A2 Q9UBY0 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7823230 0.85 SLC9A1 (0.56) SLC9A1SLC9A3SLC9A2
SCHEMBL8699590 0.82 SLC9A1 (0.56) SLC9A1SLC9A3SLC9A2
Eniporide SCHEMBL6619624 0.78 SLC9A1 (1.00) SLC9A1SLC9A3SLC9A2
Eniporide SCHEMBL29359307 0.78 SLC9A1 (1.00) SLC9A1SLC9A3SLC9A2
SCHEMBL8704441 0.78 SLC9A1 (0.59) SLC9A1SLC9A3SLC9A2
Eniporide SCHEMBL29359767 0.76 SLC9A1 (0.95) SLC9A1SLC9A3SLC9A2
SCHEMBL8448051 0.75 SLC9A1 (0.62) SLC9A1SLC9A3SLC9A2
SCHEMBL7822725 0.75 SLC9A1 (0.49) SLC9A1SLC9A3SLC9A2
SCHEMBL13602342 0.73 SLC9A1 (0.71) SLC9A1SLC9A3SLC9A2
SCHEMBL7822660 0.73 SLC9A1 (0.59) SLC9A1SLC9A3SLC9A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699666-B1 Heterocyclic substituted benzoylguanidine MERCK PATENT GMBH (DE) 1999-01-07 EP disclosed
US-5753680-A Heterocyclyl-benzoylguanidines MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1998-05-19 US disclosed
EP-0699666-A1 Heterocyclic substituted benzoylguanidine MERCK PATENT GmbH (DE) 1996-03-06 EP disclosed