SCHEMBL8447190

SCHEMBL8447190

Cc1ccc([C@H]2CC[C@H](CCc3cc(F)c(CCc4ccc(Cl)cc4)c(F)c3)CC2)cc1

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 4/20 0.37
MAOB P27338 2/20 0.37
FAAH O00519 1/20 0.35
LSS P48449 1/20 0.35
OPRL1 P41146 5/20 0.34
DRD2 P14416 3/20 0.33
DRD4 P21917 2/20 0.33
DRD3 P35462 2/20 0.33
CCR1 P32246 2/20 0.33
CNR2 P34972 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8447193 1.00 CNR1 (0.37) CNR1MAOBFAAHLSSOPRL1
SCHEMBL8447383 0.93 MAOB (0.41) CNR1MAOBFAAHCNR2
SCHEMBL8447386 0.93 MAOB (0.41) CNR1MAOBFAAHCNR2
SCHEMBL8454118 0.91 DRD2 (0.39) CNR1MAOBFAAHLSSOPRL1
SCHEMBL8454123 0.91 DRD2 (0.39) CNR1MAOBFAAHLSSOPRL1
SCHEMBL8454424 0.91 CNR1 (0.37) CNR1MAOBFAAHLSSOPRL1
SCHEMBL8454418 0.91 CNR1 (0.37) CNR1MAOBFAAHLSSOPRL1
SCHEMBL8447395 0.91 ESR2 (0.33) MAOBOPRL1
SCHEMBL8447398 0.91 ESR2 (0.33) MAOBOPRL1
SCHEMBL8451132 0.90 PROKR1 (0.35) CNR1MAOBOPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5858275-A Chlorobenzene derivative and liquid crystal composition containing the same CHISSO CORPORATION (JP) 1999-01-12 US disclosed
EP-0785179-A1 CHLOROBENZENE DERIVATIVE AND LIQUID-CRYSTAL COMPOSITION CONTAINING THE SAME CHISSO CORPORATION (JP) 1997-07-23 EP disclosed