Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 8/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9583272 | 0.89 | HPRT1 (0.42) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL10481415 | 0.89 | HPRT1 (0.39) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL10481416 | 0.88 | ALDH1A1 (0.46) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9583028 | 0.88 | HPRT1 (0.41) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9583951 | 0.87 | HPRT1 (0.40) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9595040 | 0.87 | HPRT1 (0.39) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9583714 | 0.86 | HPRT1 (0.41) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9583138 | 0.86 | MEN1 (0.38) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL10816902 | 0.86 | HPRT1 (0.39) | HPRT1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL10813801 | 0.85 | HPRT1 (0.40) | HPRT1KMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250535-A | Herpes virus; nontoxic; side effect reduction; humans and veterinary medicine | SYNTEX INC. (US) | 1993-10-05 | — | — | US | claimed |
| EP-0085424-A2 | Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl)purines as antiviral agent | SYNTEX (U.S.A.) INC. (US) | 1983-08-10 | — | — | EP | claimed |
| EP-0704445-B1 | Preparation of N-9 substituted guanine compounds | HOFFMANN LA ROCHE (CH) | 1999-04-21 | — | — | EP | disclosed |
| US-5565565-A | Preparation of N-9 substituted guanine compounds | SYNTEX (U.S.A.) INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0704445-A1 | Preparation of N-9 substituted guanine compounds | F. Hoffmann-La Roche AG (CH) | 1996-04-03 | — | — | EP | disclosed |
| US-5250535-A | Herpes virus; nontoxic; side effect reduction; humans and veterinary medicine | SYNTEX INC. (US) | 1993-10-05 | — | — | US | disclosed |
| US-4816447-A | HERPES VIRUS | MERCK & CO., INC. (US) | 1989-03-28 | — | — | US | disclosed |
| US-4803271-A | Process for preparing guanine derivatives | SYNTEX (U.S.A.) INC. (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0074306-B1 | ANTI-VIRAL GUANINE DERIVATIVES | MERCK & CO. INC. (US) | 1988-06-01 | — | — | EP | disclosed |
| US-4612314-A | Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent | SYNTEX (U.S.A.) INC. (US) | 1986-09-16 | — | — | US | disclosed |
| EP-0165164-A1 | Anti-viral compounds, their preparation and anti-viral compositions | MERCK & CO. INC. (US) | 1985-12-18 | — | — | EP | disclosed |
| EP-0085424-A2 | Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl)purines as antiviral agent | SYNTEX (U.S.A.) INC. (US) | 1983-08-10 | — | — | EP | disclosed |
| EP-0074306-A2 | Anti-viral guanine derivatives | MERCK & CO. INC. (US) | 1983-03-16 | — | — | EP | disclosed |