SCHEMBL8447490

SCHEMBL8447490

C=C(C)C(=O)OC(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.32
THRB P10828 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15157588 1.00 ALDH1A1 (0.33) ALDH1A1TSHRTHRB
SCHEMBL15157375 1.00 ALDH1A1 (0.33) ALDH1A1TSHRTHRB
SCHEMBL1444151 1.00 ALDH1A1 (0.33) ALDH1A1TSHRTHRB
SCHEMBL1444292 1.00 ALDH1A1 (0.33) ALDH1A1TSHRTHRB
SCHEMBL15156807 1.00 ALDH1A1 (0.33) ALDH1A1TSHRTHRB
SCHEMBL579310 0.93 ALDH1A1 (0.35) ALDH1A1TSHR
SCHEMBL11678497 0.92 ALDH1A1 (0.31) ALDH1A1
SCHEMBL4108175 0.90 GAA (0.35) ALDH1A1TSHR
SCHEMBL8165333 0.90 GAA (0.35) ALDH1A1TSHR
SCHEMBL1717872 0.90 GAA (0.35) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0242080-B1 COPOLYMER COMPOSITIONS PARAGON OPTICAL INC (US) 1992-12-16 EP claimed
US-4661573-A INTRAOCULAR AND CONTACT LENSES; COPOLYMER OF PERFLUROALKYL ACRYLATE, ACRYLOXYALKYLPOLYSILOXANE, ACRYLOXYALKYLSILANOL, POLYACRYLOXYALKYLPOLYSILOXANE PARAGON OPTICAL INC. (US) 1987-04-28 US claimed
US-5923397-A INTERPENETRATING NETWORK OF CROSSLINKED ACRYLIC POLYMERS; RIGID GAS PERMEABLE CORE SECTION AND SOFT EDGE SECTION ATTACHED ANNULARLY ABOUT THE CORE SECTION; EASIER TO CLEAN, PROVID GREATER VISION ACUITY AND GREATER COMFORT BAUSCH & LOMB INCORPORATED (US) 1999-07-13 US disclosed
US-5519069-A INTERPENETRATING POLYMER NETWORK, TWO CROSSLINKERS, PRECISION CASTING PILKINGTON BARNES HIND, INC. (US) 1996-05-21 US disclosed
US-5505884-A PREPARING FIRST AND SECOND MIXTURES OF POLYMERIZABLE VINYL MONOMERS, INTERRUPTING POLYMERIZATION OF THE FIRST MIXTURE BY MIXING WITH SECOND MIXTURE TO PREPARE CASTING SOLUTION, POLYMERIZING PILKINGTON BARNES HIND INC. (US) 1996-04-09 US disclosed
EP-0488627-B1 Oxygen permeable contact lens and method of manufacture therefor PILKINGTON BARNES HIND INC (US) 1996-02-14 EP disclosed
EP-0345994-B1 Contact lenses and materials and methods of making same PILKINGTON BARNES HIND INC (US) 1995-08-02 EP disclosed
EP-0242080-B1 COPOLYMER COMPOSITIONS PARAGON OPTICAL INC (US) 1992-12-16 EP disclosed
US-5170192-A Crosslinked interpenetrating network copolymers; addition polymerization PILKINGTON VISIONCARE, INC. (US) 1992-12-08 US disclosed
EP-0488627-A2 Oxygen permeable contact lens and method of manufacture therefor PARAGON VISION SCIENCES, INC. (US) 1992-06-03 EP disclosed
US-5087392-A Controlled cast molding; interrupting polymerization of first mixture of vinyl monomers by reacting with second; heating; efficient SOLA USA, INC. (US) 1992-02-11 US disclosed
US-4661573-A INTRAOCULAR AND CONTACT LENSES; COPOLYMER OF PERFLUROALKYL ACRYLATE, ACRYLOXYALKYLPOLYSILOXANE, ACRYLOXYALKYLSILANOL, POLYACRYLOXYALKYLPOLYSILOXANE PARAGON OPTICAL INC. (US) 1987-04-28 US disclosed