Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Benzamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3761120 | 0.81 | HTR2A (0.40) | CYP3A4PMP22HSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29723413 | 0.81 | HTR2A (0.40) | CYP3A4PMP22HSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6909925 | 0.79 | HTR2A (0.39) | CYP3A4PMP22HSD17B10MEN1KMT2A | |
| Fluoride Ion SCHEMBL5183865 | 0.77 | HTR2A (0.40) | CYP3A4PMP22HSD17B10MEN1KMT2A | |
| Benzamide SCHEMBL8451429 | 0.73 | PARP1 (0.47) | CYP3A4TSHRCYP2C19PARP1POLB | |
| Butyramide SCHEMBL9314122 | 0.73 | EGFR (0.32) | TSHRMEN1KMT2ASMN1; SMN2NPSR1 | |
| Benzamide SCHEMBL3870712 | 0.71 | PARP1 (0.89) | CYP3A4TSHRCYP2C19PARP1POLB | |
| Benzamide SCHEMBL8632915 | 0.71 | PARP1 (0.89) | CYP3A4TSHRCYP2C19PARP1POLB | |
| Benzamide SCHEMBL1332331 | 0.71 | — | — | |
| Benzamide SCHEMBL16352 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965758-A | Method for producing bridged type transition metal complex | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1999-10-12 | — | — | US | disclosed |