Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 8/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 5/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 5/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 5/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.37 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.37 |
| ▸ | BHMT | Q93088 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728286 | 0.89 | SLC22A6 (0.35) | NOS2 | |
| Aspartic Acid SCHEMBL28054217 | 0.76 | SLC7A5 (0.56) | SLC7A5GRIK1GRIK2SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL7204819 | 0.76 | SLC7A5 (0.56) | SLC7A5GRIK1GRIK2SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL2281229 | 0.76 | GRIK1 (0.52) | SLC7A5GRIK1GRIK2SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL7204816 | 0.76 | SLC7A5 (0.56) | SLC7A5GRIK1GRIK2SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL2281231 | 0.76 | GRIK1 (0.52) | SLC7A5GRIK1GRIK2SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL8383423 | 0.76 | SLC7A5 (0.56) | SLC7A5GRIK1GRIK2SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL8159324 | 0.76 | GRIK1 (0.52) | SLC7A5GRIK1GRIK2SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL8159323 | 0.76 | GRIK1 (0.52) | SLC7A5GRIK1GRIK2SLC1A3SLC1A2 | |
| Aspartic Acid SCHEMBL1526976 | 0.76 | GRIK1 (0.56) | SLC7A5GRIK1GRIK2SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5876623-A | ANTIDEPOSIT AGENT | NALCO CHEMICAL COMPANY (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0831066-A1 | Biodegradable Aspartic acid polymers for preventing scale formation in boilers | NALCO CHEMICAL COMPANY (US) | 1998-03-25 | — | — | EP | disclosed |