⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL866239 | 0.96 | — | — | |
| SCHEMBL22589594 | 0.87 | — | — | |
| SCHEMBL5013870 | 0.74 | — | — | |
| SCHEMBL8766900 | 0.74 | — | — | |
| SCHEMBL2219660 | 0.72 | — | — | |
| SCHEMBL11336746 | 0.72 | — | — | |
| SCHEMBL9486157 | 0.67 | — | — | |
| SCHEMBL14552664 | 0.67 | — | — | |
| SCHEMBL20676758 | 0.67 | — | — | |
| SCHEMBL9891729 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432799-B9 | CYCLOARTANONE DERIVATIVES WITH ANTI-CANCER ACTIVITY | PF MEDICAMENT (FR) | 2015-03-04 | — | — | EP | disclosed |
| EP-2432799-B1 | CYCLOARTANONE DERIVATIVES WITH ANTI-CANCER ACTIVITY | PF MEDICAMENT (FR) | 2014-09-10 | — | — | EP | disclosed |
| CN-101400680-B | Spiroindolinone derivatives | HOFFMANN LA ROCHE | 2012-04-25 | — | — | CN | disclosed |
| EP-2432799-A1 | CYCLOARTANONE DERIVATIVES WITH ANTICANCER ACTIVITY | Pierre Fabre Médicament (FR) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133687-A1 | CYCLOARTANONE DERIVATIVES WITH ANTICANCER ACTIVITY | PIERRE FABRE MEDICAMENT (FR) | 2010-11-25 | — | — | WO | disclosed |
| CN-101679448-A | spiroindolinone derivatives | HOFFMANN LA ROCHE | 2010-03-24 | — | — | CN | disclosed |
| CN-101400680-A | Spiroindolinone derivatives | HOFFMANN LA ROCHE (CH) | 2009-04-01 | — | — | CN | disclosed |
| EP-1996590-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-la Roche AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007128051-A1 | BIOLOGICAL POLYSILOXANES | VISION CRC LIMITED (AU) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007104664-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-20 | — | — | WO | disclosed |
| US-7148224-B2 | An enzyme inhibitors of cyclin-dependent kinases, antitumor agents; chemical intermediate synthesis | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-12-12 | — | — | US | disclosed |
| US-20050176719-A1 | Novel pyrazinone derivatives | MSD K.K. (JP) | 2005-08-11 | — | — | US | disclosed |
| US-6914062-B2 | Pyrazinone derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-07-05 | — | — | US | disclosed |
| EP-1295878-B1 | PYRAZINONE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2004-09-15 | — | — | EP | disclosed |
| US-20030203907-A1 | An enzyme inhibitors of cyclin-dependent kinases, antitumor agents; chemical intermediate synthesis | MSD K.K. (JP) | 2003-10-30 | — | — | US | disclosed |
| EP-1295878-A1 | NOVEL PYRAZINONE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2003-03-26 | — | — | EP | disclosed |