SCHEMBL8452019

SCHEMBL8452019

CCCCc1ccc([C@H]2CC[C@H](CCc3ccc(CCc4cc(F)c(Cl)c(F)c4)c(F)c3)CC2)cc1

nearest known ligand 0.41

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SPHK1 Q9NYA1 13/20 0.41
SPHK2 Q9NRA0 7/20 0.37
FFAR4 Q5NUL3 1/20 0.34
S1PR1 P21453 1/20 0.33
AOC3 Q16853 1/20 0.33
CYP2C9 P11712 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8452024 1.00 SPHK1 (0.41) SPHK1SPHK2FFAR4S1PR1AOC3
SCHEMBL8447324 0.97 SPHK1 (0.46) SPHK1SPHK2FFAR4S1PR1AOC3
SCHEMBL8447323 0.97 SPHK1 (0.46) SPHK1SPHK2FFAR4S1PR1AOC3
SCHEMBL8447256 0.96 SPHK1 (0.47) SPHK1SPHK2FFAR4S1PR1
SCHEMBL8452569 0.96 SPHK1 (0.47) SPHK1SPHK2FFAR4S1PR1
SCHEMBL8452561 0.96 SPHK1 (0.47) SPHK1SPHK2FFAR4S1PR1
SCHEMBL8447258 0.96 SPHK1 (0.47) SPHK1SPHK2FFAR4S1PR1
SCHEMBL8451701 0.94 MAOA (0.36) SPHK1SPHK2AOC3CYP2C9
SCHEMBL8451696 0.94 MAOA (0.36) SPHK1SPHK2AOC3CYP2C9
SCHEMBL8447751 0.94 SPHK1 (0.46) SPHK1SPHK2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5858275-A Chlorobenzene derivative and liquid crystal composition containing the same CHISSO CORPORATION (JP) 1999-01-12 US disclosed
EP-0785179-A1 CHLOROBENZENE DERIVATIVE AND LIQUID-CRYSTAL COMPOSITION CONTAINING THE SAME CHISSO CORPORATION (JP) 1997-07-23 EP disclosed