SCHEMBL8453697

SCHEMBL8453697

CCCc1ccc(C2CCC(CCc3cc(F)c(-c4ccc(Cl)c(F)c4)c(F)c3)CC2)cc1

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
SPHK1 Q9NYA1 8/20 0.34
PROKR1 Q8TCW9 2/20 0.34
CYP2C9 P11712 1/20 0.34
GPR84 Q9NQS5 1/20 0.34
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
MEN1 O00255 1/20 0.33
MAPK1 P28482 1/20 0.33
KMT2A Q03164 1/20 0.33
FFAR4 Q5NUL3 1/20 0.32
FPR2 P25090 1/20 0.32
SPHK2 Q9NRA0 4/20 0.31
P2RY14 Q15391 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8453692 1.00 MAOA (0.35) MAOAMAOBSPHK1PROKR1CYP2C9
SCHEMBL8447369 0.94 SPHK1 (0.40) SPHK1PROKR1SPHK2
SCHEMBL8447365 0.94 SPHK1 (0.40) SPHK1PROKR1SPHK2
SCHEMBL8453472 0.93 MAOB (0.39) MAOAMAOBPROKR1GPR84MAPT
SCHEMBL8453469 0.93 MAOB (0.39) MAOAMAOBPROKR1GPR84MAPT
SCHEMBL8453716 0.93 SPHK1 (0.45) SPHK1SPHK2
SCHEMBL8453708 0.93 SPHK1 (0.45) SPHK1SPHK2
SCHEMBL8456006 0.93 PROKR1 (0.35) PROKR1CYP2C9GPR84ALDH1A1LMNA
SCHEMBL8456014 0.93 PROKR1 (0.35) PROKR1CYP2C9GPR84ALDH1A1LMNA
SCHEMBL8450972 0.92 SPHK1 (0.46) SPHK1SPHK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5858275-A Chlorobenzene derivative and liquid crystal composition containing the same CHISSO CORPORATION (JP) 1999-01-12 US disclosed
EP-0785179-A1 CHLOROBENZENE DERIVATIVE AND LIQUID-CRYSTAL COMPOSITION CONTAINING THE SAME CHISSO CORPORATION (JP) 1997-07-23 EP disclosed