Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845682 | 0.95 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL845027 | 0.89 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL874311 | 0.88 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ALMNAKDM4E | |
| SCHEMBL845376 | 0.85 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AKDM4EUSP2 | |
| SCHEMBL845189 | 0.83 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2ALMNAKDM4E | |
| SCHEMBL845350 | 0.83 | MAPK1 (0.49) | ALDH1A1LMNAGAAMAPK1CYP2C9 | |
| SCHEMBL13272423 | 0.83 | GAA (0.43) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL845043 | 0.82 | ALDH1A1 (0.47) | ALDH1A1LMNAGAAMAPK1CYP2C9 | |
| SCHEMBL845337 | 0.82 | GAA (0.45) | ALDH1A1LMNAGAAKDM4EMAPK1 | |
| SCHEMBL845154 | 0.81 | ALDH1A1 (0.54) | ALDH1A1LMNAKDM4EMAPK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |