⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779829 | 0.82 | CCR1 (0.39) | — | |
| SCHEMBL21572414 | 0.78 | — | — | |
| SCHEMBL7206604 | 0.76 | CYP1A2 (0.46) | — | |
| SCHEMBL22863027 | 0.76 | — | — | |
| SCHEMBL2131248 | 0.76 | MEN1 (0.42) | — | |
| SCHEMBL11149234 | 0.76 | CYP1A2 (0.46) | — | |
| SCHEMBL30602371 | 0.76 | KMT2A (0.42) | — | |
| SCHEMBL12879681 | 0.76 | KMT2A (0.42) | — | |
| SCHEMBL2964870 | 0.75 | — | — | |
| SCHEMBL13199667 | 0.73 | MEN1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230140395-A1 | NOVEL IMIDAZOLE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND USE THEREOF | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS (KR) | 2023-05-04 | — | — | US | disclosed |
| US-20230140395-A1 | NOVEL IMIDAZOLE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND USE THEREOF | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS (KR) | 2023-05-04 | — | — | US | disclosed |
| WO-2023028489-A1 | COMPOSITIONS AND METHODS FOR TREATING PROTEOTOXICITY-ASSOCIATED DISEASES | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-03-02 | — | — | WO | disclosed |
| US-9994591-B2 | Oxadiazolopyridine derivates for use as ghrelin O-acyl transferase (GOAT) inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-12 | — | — | US | disclosed |
| US-20180037594-A1 | Oxadiazolopyridine Derivates for Use as Ghrelin O-Acyl Transferase (GOAT) Inhibitors | BOEHRINGER INGELHEIM INERNATIONAL GMBH (DE) | 2018-02-08 | — | — | US | disclosed |
| US-9334274-B2 | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2016-05-10 | — | — | US | disclosed |
| US-20140221379-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2014-08-07 | — | — | US | disclosed |
| US-8716303-B2 | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors | INCYTE CORPORATION (US) | 2014-05-06 | — | — | US | disclosed |
| EP-2432555-B1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-D]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-D]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORP (US) | 2014-04-30 | — | — | EP | disclosed |
| WO-2012069601-A1 | SUBSTITUTED QUINAZOLINES AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-05-31 | — | — | WO | disclosed |
| WO-2010135650-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2010-11-25 | — | — | WO | disclosed |
| US-20100298334-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION | 2010-11-25 | — | — | US | disclosed |
| EP-2003116-A9 | PROCESS FOR THE PRODUCTION OF ORGANIC OXIDES | Takeda Pharmaceutical Company Limited (JP) | 2009-05-20 | — | — | EP | disclosed |
| US-20090054655-A1 | Process for the Production of Organic Oxides | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-2003116-A2 | PROCESS FOR THE PRODUCTION OF ORGANIC OXIDES | Takeda Pharmaceutical Company Limited (JP) | 2008-12-17 | — | — | EP | disclosed |
| US-4409228-A | ANOREXIGENIC AGENTS | SANOFI (FR) | 1983-10-11 | — | — | US | disclosed |
| EP-0045980-B1 | COMPOUNDS USEFUL IN THE PREPARATION OF AMINOPIPERIDINES WITH ANORECTIC PROPERTIES | SANOFI S.A. (FR) | 1983-10-05 | — | — | EP | disclosed |
| EP-0021973-B1 | ANORECTIC AMINO PIPERIDINES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | SANOFI S.A. (FR) | 1982-12-08 | — | — | EP | disclosed |
| EP-0045980-A1 | Compounds useful in the preparation of aminopiperidines with anorectic properties | SANOFI S.A. (FR) | 1982-02-17 | — | — | EP | disclosed |
| EP-0021973-A2 | Anorectic amino piperidines, process for their preparation and medicaments containing them | SANOFI S.A. (FR) | 1981-01-07 | — | — | EP | disclosed |