SCHEMBL8455758

SCHEMBL8455758

FC(F)(F)Oc1ccc(C2CCC(c3ccccc3)CC2)cc1

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
KDM1A O60341 2/20 0.49
GRIN2B Q13224 2/20 0.48
GRM2 Q14416 1/20 0.47
CCR6 P51684 1/20 0.43
KCNH2 Q12809 1/20 0.43
KIF11 P52732 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
SLC18A3 Q16572 1/20 0.42
SIGMAR1 Q99720 1/20 0.42
RCOR1 Q9UKL0 1/20 0.42
BCHE P06276 3/20 0.42
ACHE P22303 3/20 0.42
BACE1 P56817 3/20 0.42
FAAH O00519 1/20 0.41
F2R P25116 2/20 0.40
ATM Q13315 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4564168 0.92 L3MBTL1 (0.47) MEN1KMT2AKDM1AGRIN2BGRM2
SCHEMBL28247613 0.85 MEN1 (0.48) MEN1KMT2AKDM1AGRIN2BL3MBTL1
SCHEMBL14229002 0.84 ESR2 (0.52) MEN1KMT2AKDM1AL3MBTL1RCOR1
SCHEMBL22816126 0.84 ESR2 (0.53) MEN1KMT2AKDM1AGRM2KCNH2
SCHEMBL8596553 0.84 L3MBTL1 (0.42) MEN1KMT2AKDM1AGRM2L3MBTL1
SCHEMBL14817292 0.84 ESR2 (0.53) MEN1KMT2AKDM1AGRM2KCNH2
SCHEMBL8596557 0.84 KDM1A (0.44) MEN1KMT2AKDM1AGRM2L3MBTL1
SCHEMBL22816583 0.84 ESR2 (0.53) MEN1KMT2AKDM1AGRM2KCNH2
SCHEMBL8596551 0.84 L3MBTL1 (0.42) MEN1KMT2AKDM1AGRM2L3MBTL1
SCHEMBL7724468 0.83 EPHX2 (0.48) MEN1KMT2AKDM1AKCNH2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0394419-B2 MATRIX LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 1999-10-06 EP disclosed