Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8460637 | 0.91 | ALDH1A1 (0.42) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL8461387 | 0.89 | ALDH1A1 (0.43) | ALDH1A1KMT2AKDM4EHPGDTDP1 | |
| SCHEMBL8459317 | 0.89 | KMT2A (0.45) | ALDH1A1KMT2AMEN1L3MBTL1NCEH1 | |
| SCHEMBL7608625 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL8058577 | 0.79 | CYP1A2 (0.41) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL18050514 | 0.76 | NCEH1 (0.51) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL15535471 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL7611156 | 0.74 | HTT (0.39) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL7613495 | 0.74 | NCEH1 (0.41) | ALDH1A1KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL7605243 | 0.72 | HTT (0.38) | ALDH1A1KMT2AMEN1LMNANCEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | disclosed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | disclosed |