Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | DRD3 | P35462 | 3/20 | 0.73 |
| ▸ | HTR2A | P28223 | 2/20 | 0.73 |
| ▸ | HTR2B | P41595 | 2/20 | 0.73 |
| ▸ | BLM | P54132 | 2/20 | 0.73 |
| ▸ | CNR1 | P21554 | 1/20 | 0.73 |
| ▸ | APEX1 | P27695 | 1/20 | 0.73 |
| ▸ | PDE4A | P27815 | 1/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.73 |
| ▸ | DRD2 | P14416 | 2/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | CYP2J2 | P51589 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.63 |
| ▸ | GMNN | O75496 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8454720 | 0.99 | HRH1 (0.74) | HRH1KCNH2LMNADRD3HTR2A | |
| Hydrochloric Acid SCHEMBL8454992 | 0.98 | HRH1 (0.72) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL8678278 | 0.92 | HRH1 (0.68) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL29120622 | 0.91 | HRH1 (0.64) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL10526656 | 0.89 | HRH1 (0.71) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL2456709 | 0.86 | HRH1 (0.74) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL8678047 | 0.86 | HRH1 (0.68) | HRH1KCNH2LMNADRD3HTR2A | |
| Fexofenadine SCHEMBL1561082 | 0.84 | HRH1 (1.00) | HRH1KCNH2LMNADRD3HTR2A | |
| Fexofenadine SCHEMBL1972366 | 0.84 | HRH1 (1.00) | HRH1KCNH2LMNADRD3HTR2A | |
| Fexofenadine SCHEMBL3178320 | 0.84 | HRH1 (1.00) | HRH1KCNH2LMNADRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932247-A | MICROCRYSTALLINE CELLULOSE, LACTOSE AND PREGELATINIZED STARCH; GELATIN; CROSCARMELLOSE SODIUM | HOECHST MARION ROUSSEL, INC. (US) | 1999-08-03 | — | — | US | disclosed |
| US-5925761-A | Synthesis of terfenadine and derivatives | SEPRACOR INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5855912-A | Pharmaceutical compositions for piperidinalkanol compounds | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-05 | — | — | US | disclosed |
| US-5750703-A | Piperidine derivatives and process for their production | ALBANY MOLECULAR RESEARCH, INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5738872-A | ANTIALLERGENS, ANTIHISTAMINES; BIOAVAILABILITY | HOECHST MARION ROUSSEL, INC. (US) | 1998-04-14 | — | — | US | disclosed |
| US-5675009-A | Process for piperidine derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-10-07 | — | — | US | disclosed |