Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | DRD2 | P14416 | 8/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 5/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84567 | 0.90 | HTR2A (0.55) | HTR2ADRD3DRD2SLC6A4ACHE | |
| SCHEMBL84565 | 0.88 | HTR2A (0.61) | HTR2ADRD3DRD2SLC6A4ACHE | |
| SCHEMBL85017 | 0.85 | DRD2 (0.48) | HTR2ADRD3DRD2SLC6A4ACHE | |
| SCHEMBL84562 | 0.84 | DRD2 (0.53) | HTR2ADRD2HTR1AHTR7 | |
| SCHEMBL19957359 | 0.82 | DRD2 (0.66) | HTR2ADRD3DRD2SLC6A4ACHE | |
| SCHEMBL13525309 | 0.82 | HTR2A (0.56) | HTR2ADRD3DRD2SLC6A4ACHE | |
| SCHEMBL23175518 | 0.81 | HTR2A (0.51) | HTR2ADRD3DRD2SLC6A4ACHE | |
| SCHEMBL14587854 | 0.81 | HTR2A (0.62) | HTR2ADRD3DRD2SLC6A4ACHE | |
| SCHEMBL84574 | 0.80 | DRD2 (0.60) | HTR2ADRD3DRD2SLC6A4ACHE | |
| Hydrochloric Acid SCHEMBL606382 | 0.79 | HTR2A (0.70) | HTR2ADRD3DRD2SLC6A4ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129410-B2 | Sleep maintenance insomnia; circadian rhythm abnormalities; side effect reduction | HYPNION, INC. (US) | 2012-03-06 | — | — | US | disclosed |