Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981886 | 0.81 | KDM4E (0.49) | SMN1; SMN2LMNAKDM4EALDH1A1RAB9A | |
| SCHEMBL27454948 | 0.78 | CNR2 (0.34) | — | |
| SCHEMBL28050378 | 0.75 | TDP1 (0.36) | SMN1; SMN2LMNAKDM4EL3MBTL1ATM | |
| SCHEMBL27426157 | 0.73 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAKDM4EATMMAPK1 | |
| SCHEMBL5000372 | 0.73 | MAPT (0.38) | SMN1; SMN2ATMMAPK1POLBALDH1A1 | |
| SCHEMBL1828029 | 0.72 | SLC9A1 (0.47) | SMN1; SMN2LMNAKDM4EL3MBTL1MAPK1 | |
| SCHEMBL28147308 | 0.72 | SLC9A1 (0.41) | SMN1; SMN2LMNAATMMAPK1POLB | |
| SCHEMBL27400199 | 0.72 | KDM4E (0.38) | KDM4EATMMAPK1POLBALDH1A1 | |
| SCHEMBL27380231 | 0.71 | CYP1A2 (0.41) | SMN1; SMN2LMNAKDM4EL3MBTL1ATM | |
| SCHEMBL28034903 | 0.71 | HPGD (0.40) | SMN1; SMN2LMNAKDM4EPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888336-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997030989-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-08-28 | — | — | WO | disclosed |