SCHEMBL8458265

SCHEMBL8458265

COC1CCN(c2c(Cl)cc3c4c(cccc24)CN(O)C3)C1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.38
PRKAB2 O43741 2/20 0.34
PRKAG1 P54619 2/20 0.34
PRKAA2 P54646 2/20 0.34
PRKAA1 Q13131 2/20 0.34
PRKAG3 Q9UGI9 2/20 0.34
PRKAG2 Q9UGJ0 2/20 0.34
PRKAB1 Q9Y478 2/20 0.34
HTR6 P50406 2/20 0.33
NOTUM Q6P988 1/20 0.33
MGLL Q99685 1/20 0.33
IDH1 O75874 2/20 0.33
USP30 Q70CQ3 1/20 0.32
BRD1 O95696 1/20 0.32
TAF1 P21675 1/20 0.32
BRPF1 P55201 1/20 0.32
PDE10A Q9Y233 1/20 0.32
SCD O00767 2/20 0.32
SCD5 Q86SK9 2/20 0.32
RORC P51449 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7709715 0.77 POLB (0.46) MAOBPRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL7709561 0.69 BRD1 (0.40) MAOBPRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL21668750 0.65 NOTUM (0.54) MAOBNOTUMPDE10ASCD
SCHEMBL8582260 0.64 MEN1 (0.34)
SCHEMBL2164144 0.63 ALDH1A1 (0.45) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL15676606 0.62 KLKB1 (0.46) NOTUM
SCHEMBL2163266 0.61 ALDH1A1 (0.38) MAOB
SCHEMBL24681518 0.60 NOTUM (0.51) NOTUMUSP30
SCHEMBL24681521 0.60 NOTUM (0.51) NOTUMUSP30
SCHEMBL24681616 0.60 NOTUM (0.51) NOTUMUSP30

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0939754-A2 N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 1999-09-08 EP disclosed
WO-1998019648-A2 N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 1998-05-14 WO disclosed