Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8732951 | 0.87 | NPSR1 (0.50) | POLBTSHRALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8457131 | 0.79 | TSHR (0.49) | POLBTSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4422382 | 0.78 | POLB (0.47) | POLBTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8459534 | 0.77 | CA12 (0.47) | TSHRLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28864257 | 0.76 | POLB (0.49) | POLBTSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL17045877 | 0.76 | POLB (0.54) | POLBTSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8154438 | 0.76 | TSHR (0.49) | POLBTSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8458503 | 0.76 | CA12 (0.46) | TSHRLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL4558544 | 0.76 | CFTR (0.60) | POLBTSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL17052738 | 0.75 | POLB (0.53) | POLBTSHRLMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880112-A | PHOSPHINIC ACID DERIVATIVES; PROSTATE CANCER TREATMENT | GUILFORD PHARMACEUTICALS INC. (US) | 1999-03-09 | — | — | US | claimed |
| US-5880112-A | PHOSPHINIC ACID DERIVATIVES; PROSTATE CANCER TREATMENT | GUILFORD PHARMACEUTICALS INC. (US) | 1999-03-09 | — | — | US | disclosed |
| US-5804602-A | N-ACETYLATED ALPHA-LINKED ACIDIC DIPEPTIDASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-09-08 | — | — | US | disclosed |
| US-5672592-A | HYDROLASE INHIBITORS, ANTITUMOR AND ANTICARCINOGENIC AGENTS, FOR PROSTATE CANCER | GUILFORD PHARMACEUTICALS INC. (US) | 1997-09-30 | — | — | US | disclosed |