SCHEMBL8458472

SCHEMBL8458472

O=C(O)C(c1ccccc1)C(c1ccsc1)[PH](=O)O

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.47
IDO1 P14902 1/20 0.40
TDO2 P48775 1/20 0.40
HPGD P15428 1/20 0.36
SRC P12931 1/20 0.35
ALOX5 P09917 1/20 0.35
LMNA P02545 2/20 0.34
MAPK1 P28482 1/20 0.34
KMT2A Q03164 1/20 0.34
SLC6A2 P23975 1/20 0.34
SLC6A3 Q01959 1/20 0.34
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
SLC6A9 P48067 1/20 0.33
SLC6A5 Q9Y345 1/20 0.33
LCK P06239 1/20 0.33
FYN P06241 1/20 0.33
DAO P14920 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8458492 0.76 CYP2D6 (0.47) CYP2D6SRCALOX5LMNAMAPK1
SCHEMBL8460780 0.75 CYP2D6 (0.50) CYP2D6SRCLMNAKMT2ASLC6A2
SCHEMBL18734632 0.74 CYP2D6 (0.50) CYP2D6IDO1TDO2HPGDSRC
SCHEMBL27862589 0.73 CYP2D6 (0.47) CYP2D6IDO1TDO2SRCALOX5
SCHEMBL8461160 0.73 SMN1; SMN2 (0.47) CYP2D6HPGDLMNASLC6A2SLC6A3
SCHEMBL7650063 0.72 LCK (0.34) ALOX5LCKFYNDAO
SCHEMBL8580097 0.72 TDP1 (0.48) CYP2D6IDO1TDO2HPGDSRC
SCHEMBL15768409 0.70 IDO1 (0.40) IDO1TDO2HPGDALOX5SLC6A2
SCHEMBL8460781 0.70 CYP2D6 (0.47) CYP2D6LMNASLC6A2SLC6A3
SCHEMBL14671259 0.70 ALOX5 (0.42) CYP2D6IDO1TDO2HPGDALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0936914-A1 HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS GUILFORD PHARMACEUTICALS INC. (US) 1999-08-25 EP disclosed
EP-0936914-A4 1999-08-25 EP disclosed
WO-1997048400-A1 HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS GUILFORD PHARMACEUTICALS INC. (US) 1997-12-24 WO disclosed