Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | RXRA | P19793 | 7/20 | 0.55 |
| ▸ | KDM1A | O60341 | 2/20 | 0.50 |
| ▸ | RARB | P10826 | 7/20 | 0.46 |
| ▸ | RARG | P13631 | 6/20 | 0.46 |
| ▸ | RARA | P10276 | 4/20 | 0.46 |
| ▸ | RXRB | P28702 | 4/20 | 0.45 |
| ▸ | RXRG | P48443 | 3/20 | 0.45 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.45 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9418960 | 0.86 | MAPT (0.55) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL9418965 | 0.83 | RARB (0.64) | ALDH1A1KDM4EPOLBBLMCYP2C19 | |
| SCHEMBL9418967 | 0.83 | RARB (0.64) | ALDH1A1KDM4EPOLBBLMCYP2C19 | |
| SCHEMBL9477896 | 0.82 | ALDH1A1 (0.83) | ALDH1A1KDM4EMAPTPOLBBLM | |
| Hydrochloric Acid SCHEMBL10587733 | 0.81 | ALDH1A1 (0.80) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL17551922 | 0.79 | KDM4E (0.60) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL18213884 | 0.79 | KDM4E (0.60) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL485369 | 0.79 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL31506355 | 0.79 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL1713977 | 0.79 | ALDH1A1 (0.92) | ALDH1A1KDM4EMAPTPOLBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410358-B1 | AROMATIC CARBOXYLIC ACID AMIDES, THEIR PREPARATION AND THEIR USE AS MEDICINES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-09-29 | — | — | EP | claimed |
| US-5128470-A | Aantiinflammatory, antiallergens | HOFFMANN-LA ROCHE INC. (US) | 1992-07-07 | — | — | US | claimed |
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |
| EP-0410358-B1 | AROMATIC CARBOXYLIC ACID AMIDES, THEIR PREPARATION AND THEIR USE AS MEDICINES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-09-29 | — | — | EP | disclosed |
| US-5216153-A | Therapy and prophylaxis for skin, autoimmune and rheumatic diseases | HOFFMANN-LA ROCHE INC. (US) | 1993-06-01 | — | — | US | disclosed |
| US-5128470-A | Aantiinflammatory, antiallergens | HOFFMANN-LA ROCHE INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0410358-A1 | Aromatic carboxylic acid amides, their preparation and their use as medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1991-01-30 | — | — | EP | disclosed |