Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8459779 | 0.80 | CYP2A6 (0.37) | CYP2A6AOC3BRD4NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8462413 | 0.78 | FLT3 (0.33) | CYP2A6AOC3BRD4ALOX5NPC1 | |
| Hydrochloric Acid SCHEMBL8463285 | 0.70 | CYP2A6 (0.33) | CYP2A6AOC3BRD4NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8459502 | 0.69 | KDM4E (0.36) | CYP2A6AOC3BRD4NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8462951 | 0.67 | AOC3 (0.47) | CYP2A6AOC3BRD4NPC1RAB9A | |
| Indene SCHEMBL4447982 | 0.63 | BRD4 (0.32) | BRD4KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL8463556 | 0.63 | AOC3 (0.42) | CYP2A6AOC3BRD4NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL9010289 | 0.62 | KDM4E (0.33) | CYP2A6AOC3BRD4NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8460029 | 0.61 | BRD4 (0.37) | CYP2A6AOC3BRD4NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8463428 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741145-B1 | Olefin polymerization catalyst and process for producing polyolefin using the same | SUMITOMO CHEMICAL CO (JP) | 1999-12-29 | — | — | EP | disclosed |