Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.89 |
| ▸ | ITGA2B | P08514 | 17/20 | 0.89 |
| ▸ | ITGAV | P06756 | 6/20 | 0.68 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.49 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7488060 | 0.88 | ITGB3 (0.98) | ITGB3ITGA2BITGAVITGB5 | |
| Trifluoroacetic Acid SCHEMBL7495244 | 0.85 | ITGB3 (0.66) | ITGB3ITGA2BITGAV | |
| Trifluoroacetic Acid SCHEMBL7222227 | 0.84 | ITGB3 (0.64) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| Trifluoroacetic Acid SCHEMBL7223027 | 0.83 | ITGB3 (0.61) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| Trifluoroacetic Acid SCHEMBL7222308 | 0.83 | ITGB3 (0.61) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL7487559 | 0.83 | ITGB3 (0.76) | ITGB3ITGA2BITGAVITGB5 | |
| Trifluoroacetic Acid SCHEMBL7222559 | 0.82 | ITGB3 (0.61) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| Trifluoroacetic Acid SCHEMBL7221135 | 0.82 | ITGB3 (0.64) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| Trifluoroacetic Acid SCHEMBL7222095 | 0.81 | ITGB3 (0.62) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| Trifluoroacetic Acid SCHEMBL7216309 | 0.81 | ITGB3 (0.62) | ITGB3ITGA2BITGAVITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929120-A | Guainidino, formamidino, amino and related compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1999-07-27 | — | — | US | disclosed |
| US-5741796-A | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1998-04-21 | — | — | US | disclosed |
| EP-0760658-A4 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO INC (US) | 1997-09-17 | — | — | EP | disclosed |
| EP-0760658-A1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO. INC. (US) | 1997-03-12 | — | — | EP | disclosed |
| WO-1995032710-A1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO., INC. (US) | 1995-12-07 | — | — | WO | disclosed |