Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | GOT1 | P17174 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8458430 | 0.92 | HIF1A (0.41) | PTPN11HIF1AEPAS1IKBKBCNR2 | |
| SCHEMBL8457308 | 0.90 | PTPN11 (0.39) | PTPN11HIF1AEPAS1IKBKBCNR2 | |
| SCHEMBL8458373 | 0.88 | PTPN11 (0.40) | PTPN11HIF1AEPAS1IKBKBCNR2 | |
| SCHEMBL7929851 | 0.84 | RARB (0.45) | PTPN11HIF1AEPAS1IKBKBMAPK1 | |
| SCHEMBL7927824 | 0.80 | HIF1A (0.43) | HIF1AEPAS1IKBKBLMNAKMT2A | |
| SCHEMBL7920646 | 0.77 | RARB (0.48) | PTPN11HIF1AEPAS1IKBKBMAPK1 | |
| SCHEMBL8457995 | 0.76 | PTPN11 (0.44) | PTPN11IKBKBCNR2MAPK1FAAH | |
| SCHEMBL8457985 | 0.75 | PTPN11 (0.43) | PTPN11HIF1AEPAS1IKBKBCNR2 | |
| SCHEMBL8459775 | 0.75 | HIF1A (0.43) | HIF1AEPAS1CNR2FAAHCNR1 | |
| SCHEMBL7930122 | 0.74 | HIF1A (0.43) | HIF1AEPAS1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952382-A | INHIBITING THE BIOLOGICAL EFFECTS OF AN OVERREGULATION OF RETINOID ACID RECEPTORS AND/OR OF A HYPERVITAMINOSIS A; TREATING SKIN DISORDER, EYE VISION DEFECTS, SKIN AGING | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-09-14 | — | — | US | claimed |
| US-5952382-A | INHIBITING THE BIOLOGICAL EFFECTS OF AN OVERREGULATION OF RETINOID ACID RECEPTORS AND/OR OF A HYPERVITAMINOSIS A; TREATING SKIN DISORDER, EYE VISION DEFECTS, SKIN AGING | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-09-14 | — | — | US | disclosed |