SCHEMBL8459772

SCHEMBL8459772

Cc1ccc(-c2ccccc2)c(F)c1F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.45
ALOX5AP P20292 2/20 0.44
FEN1 P39748 2/20 0.44
CYP2A6 P11509 1/20 0.43
CYP2B6 P20813 1/20 0.43
HTT P42858 1/20 0.38
ACHE P22303 1/20 0.37
AKT1 P31749 1/20 0.36
AKT2 P31751 1/20 0.36
PTGS1 P23219 3/20 0.36
MEN1 O00255 2/20 0.36
PTGS2 P35354 2/20 0.36
KMT2A Q03164 2/20 0.36
CYP1A2 P05177 2/20 0.36
FABP2 P12104 1/20 0.36
TSHR P16473 1/20 0.36
AKR1C4 P17516 1/20 0.36
ADRA2B P18089 1/20 0.36
CHRM3 P20309 1/20 0.36
HTR2C P28335 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL27687172 0.98 ESR2 (0.44) ESR2ALOX5APFEN1CYP2A6CYP2B6
Methane SCHEMBL27747305 0.98 ESR2 (0.44) ESR2ALOX5APFEN1CYP2A6CYP2B6
SCHEMBL25954438 0.96 ESR2 (0.42) ESR2ALOX5APFEN1CYP2A6CYP2B6
SCHEMBL23789229 0.94 ESR2 (0.41) ESR2ALOX5APFEN1CYP2A6CYP2B6
SCHEMBL803253 0.88 PTGS2 (0.38) ESR2ALOX5APFEN1PTGS1PTGS2
SCHEMBL10533047 0.85 ALOX5AP (0.53) ESR2ALOX5APFEN1CYP2A6PTGS1
SCHEMBL10263187 0.84 ESR2 (0.44) ESR2ALOX5APFEN1CYP2A6CYP2B6
SCHEMBL13262957 0.84 PTPRC (0.44) ACHEMEN1KMT2AMAPTALDH1A1
SCHEMBL12716080 0.83 PDK2 (0.38) ESR2ALOX5APFEN1CYP2A6CYP2B6
SCHEMBL15856389 0.83 ESR2 (0.42) ESR2ALOX5APFEN1CYP2A6CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117865773-A Preparation method of difluoromethyl aromatic compound based on palladium-catalyzed decarbonylation coupling 大连理工大学 2024-04-12 CN disclosed
EP-2206695-B1 TETRA- OR PENTA-CYCLIC LIQUID CRYSTALLINE COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT JNC CORP (JP) 2013-09-18 EP disclosed
US-20130207038-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2013-08-15 US disclosed
EP-2206695-A1 TETRA- OR PENTA-CYCLIC LIQUID CRYSTALLINE COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT Chisso Corporation (JP) 2010-07-14 EP disclosed
EP-0934237-A1 TETRACYCLIC COMPOUND HAVING LATERAL HALOGEN SUBSTITUENT AND LIQUID CRYSTAL COMPOSITION COMPRISING THE SAME CHISSO CORPORATION (JP) 1999-08-11 EP disclosed
WO-1998008792-A1 TETRACYCLIC COMPOUND HAVING LATERAL HALOGEN SUBSTITUENT AND LIQUID CRYSTAL COMPOSITION COMPRISING THE SAME CHISSO CORPORATION (JP) 1998-03-05 WO disclosed