Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levallorphan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 9/20 | 0.98 |
| ▸ | OPRK1 known ✓ | P41145 | 6/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | HTT | P42858 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | ACHE | P22303 | 1/20 | 0.98 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.98 |
| ▸ | DRD3 | P35462 | 1/20 | 0.98 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.84 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.67 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.67 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.67 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.67 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.67 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.67 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.67 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levallorphan SCHEMBL678413 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1KCNH2ALDH1A1LMNA | |
| Dextallorphan SCHEMBL29438705 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1KCNH2ALDH1A1LMNA | |
| Levallorphan SCHEMBL20505815 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1KCNH2ALDH1A1LMNA | |
| Levallorphan SCHEMBL12232843 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1KCNH2ALDH1A1LMNA | |
| Levallorphan SCHEMBL16311899 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1KCNH2ALDH1A1LMNA | |
| Levallorphan SCHEMBL12233279 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1KCNH2ALDH1A1LMNA | |
| Levallorphan SCHEMBL29368769 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1KCNH2ALDH1A1LMNA | |
| Levallorphan SCHEMBL209271 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1KCNH2ALDH1A1LMNA | |
| Levallorphan SCHEMBL34060 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1KCNH2ALDH1A1LMNA | |
| Levallorphan SCHEMBL5675160 | 0.96 | OPRM1 (0.94) | OPRM1OPRK1KCNH2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693479-B1 | ACONITINE-LIKE COMPOUND AND ANTIPYRETIC ANALGESIC ANTI-INFLAMMATORY AGENT | SANWA SHOYAKU KK (JP) | 1999-10-13 | — | — | EP | disclosed |
| US-5770604-A | MORPHINE SIDE EFFECT REDUCTION | SANWA SHOYAKU KABUSHIKI KAISHA (JP) | 1998-06-23 | — | — | US | disclosed |
| EP-0693479-A1 | NOVEL ACONITINE-LIKE COMPOUND AND ANTIPYRETIC ANALGESIC ANTI-INFLAMMATORY AGENT | SANWA SHOYAKU KABUSHIKI KAISHA (JP) | 1996-01-24 | — | — | EP | disclosed |