Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 1.00 |
| ▸ | RXRB | P28702 | 7/20 | 1.00 |
| ▸ | NR4A2 | P43354 | 5/20 | 1.00 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.70 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | RXRG | P48443 | 2/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.62 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.61 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813418 | 1.00 | RXRA (1.00) | RXRARXRBNR4A2NR4A1NR4A3 | |
| SCHEMBL24464736 | 0.88 | RXRA (0.78) | RXRARXRBNR4A2NR4A1NR4A3 | |
| SCHEMBL28224182 | 0.88 | NR4A2 (0.78) | RXRARXRBNR4A2NR4A1NR4A3 | |
| SCHEMBL8457176 | 0.87 | RXRA (0.76) | RXRARXRBNR4A2NR4A1NR4A3 | |
| SCHEMBL8134318 | 0.87 | NR4A2 (0.85) | RXRARXRBNR4A2NR4A1NR4A3 | |
| SCHEMBL8462073 | 0.86 | RXRA (0.76) | RXRARXRBNR4A2NR4A1NR4A3 | |
| SCHEMBL9509148 | 0.85 | NR4A2 (0.74) | RXRARXRBNR4A2NR4A1NR4A3 | |
| SCHEMBL13439695 | 0.85 | NR4A2 (0.74) | RXRARXRBNR4A2NR4A1NR4A3 | |
| SCHEMBL10396483 | 0.85 | NR4A2 (0.74) | RXRARXRBNR4A2NR4A1NR4A3 | |
| SCHEMBL22275947 | 0.85 | APP (0.82) | RXRARXRBNR4A2NR4A1NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |